The Effect of Contrast Enhancement on Retinal Blood Vessel Segmentation Using CAS-UNet with Coordinate Attention
DOI:
https://doi.org/10.30872/jim.v21i1.26937Keywords:
retinal blood vessel segmentation, contrast enhancement, CAS-UNet, coordinate attention, CLAHE, citra fundus,Abstract
Low contrast variation, uneven intensity distribution, and the presence of noise in retinal fundus images pose major challenges for blood vessel segmentation, particularly regarding thin and complex structures. These conditions make it difficult for models to accurately distinguish between blood vessels and the background. This study aims to analyze the impact of contrast enhancement techniques on retinal blood vessel segmentation performance using a CAS-UNet architecture modified with Coordinate Attention (CA). The methodology involves three preprocessing scenarios: Grayscale, Grayscale + CLAHE, and Grayscale + CLAHE + Gamma Correction. The model was trained using the DRIVE and CHASE_DB1 datasets with an 80:20 data split, an SGD optimizer, a learning rate of 0.01, and a combined BCE and Dice loss function over 50 epochs. Evaluation was conducted using a confusion matrix based on accuracy, sensitivity, specificity, F1-score, and IoU metrics. The results indicate that the Grayscale + CLAHE combination yielded the best performance—achieving a sensitivity of 81.46%, an F1-score of 81.63%, and an IoU of 69.01%—while also improving the detection of small blood vessels more consistently. These findings demonstrate that the appropriate application of contrast enhancement plays a crucial role in improving the quality of medical image segmentation.References
Agustianto, K., Choirunnisa, S., Afianah, N., & Huda, C. (2022). Deteksi Pembuluh Darah pada Citra Fundus Retina Menggunakan Gabungan Metode Segementasi Pembuluh Darah Lebar dan Tipis. Jurnal Teknologi Informasi Dan Terapan, 9(1), 41–46. https://doi.org/10.25047/jtit.v9i1.276
Amir, S. B. H., Akbar, S. N. A. F., Hendra, H., Anwar, A. M., & Sulfayanti, S. (2023). Deteksi Citra X-Ray Paru-Paru Terinfeksi COVID-19 dengan Algoritma CNN berbasis Aplikasi Web. Informatika Mulawarman: Jurnal Ilmiah Ilmu Komputer, 17(1), 37–41.
Ariadi, K., Anggraeny, F. T., & Sihananto, A. N. (2024). Perbandingan Performa Metode SVM dan KNN dalam Mengklarifikasi Citra Iinfeksi Telinga. JATI (Jurnal Mahasiswa Teknik Informatika), 8(6), 11342–11347.
Attaqwa, S. I., Puspaningrum, E. Y., & Saputra, W. S. J. (2024). Implementasi Contrast Limited Adaptive Histogram Equalization dalam Pengolahan Citra pada Algoritma Generative Adversarial Network. Jurnal Informatika Dan Teknik Elektro Terapan, 12(3S1).
Barman, S., Hoppe, A., Fraz, M. M., Uyyanonvara, B., Rudnicka, A. R., & Owen, C. G. (2012). CHASE_DB1 retinal vessel reference dataset. https://doi.org/10.1109/TBME.2012.2205687
Chazar, C., Adli, M. A., Pardede, J., & Ichwan, M. (2025). Pendekatan Augmentasi Citra Fundus pada Model EfficientNet untuk Klasifikasi Tingkat Keparahan Retinopati Diabetik dengan Dataset Tidak Seimbang. MIND (Multimedia Artificial Intelligent Networking Database) Journal, 10(2), 180–194.
Das, S., Chakraborty, S., Mishra, M., & Majumder, S. (2024). Assessment of retinal blood vessel segmentation using U-Net model: A deep learning approach. Franklin Open, 8(January), 100143. https://doi.org/10.1016/j.fraope.2024.100143
Desiani, A., Zayanti, D. A., Primartha, R., Efriliyanti, F., & Andriani, N. A. C. (2021). Variasi Thresholding untuk Segmentasi Pembuluh Darah Citra Retina. Jurnal Edukasi Dan Penelitian Informatika (JEPIN), 7(2), 255. https://doi.org/10.26418/jp.v7i2.47205
Galgani, F. (2024). What Is Gamma Correction? Retrieved from Baeldung website: https://www.baeldung.com/cs/gamma-correction-brightness
Herawati, I. A. M., Sindu Putra, I. B. K., & Suyanta, I. W. (2023). Meningkatkan Literasi Lingkungan Anak Usia 5-6 Tahun Melalui Projek Eco Enzyme. Kumara Cendekia, 11(3), 251. https://doi.org/10.20961/kc.v11i3.76862
Hernandez-Gutierrez, F. D., Avina-Bravo, E. G., Ibarra-Manzano, M. A., Ruiz-Pinales, J., Ovalle-Magallanes, E., & Avina-Cervantes, J. G. (2025). Retinal Vessel Segmentation Based on a Lightweight U-Net and Reverse Attention. Mathematics, Vol. 13, p. 2203. https://doi.org/10.3390/math13132203
Hidayat, J., & Fitriani, A. (2025). Perbandingan Metode Power Law Dengan Contrast Limited Adaptive Histogram Equalization (Clahe) Pada Perbaikan Kualitas Citra Satelit. RELE (Rekayasa Elektrikal Dan Energi): Jurnal Teknik Elektro, 8(1), 301–306.
Hou, Q., Zhou, D., & Feng, J. (2021). Coordinate Attention for Efficient Mobile Network Design. Conference on Computer Vision and Pattern Recognition (CVPR), 13713–13722.
Kabiraj, A., Pal, D., Ganguly, D., Chatterjee, K., & Roy, S. (2023). Number plate recognition from enhanced super-resolution using generative adversarial network. Multimedia Tools and Applications, 82(9), 13837–13853.
Kande, G. B., Nalluri, M. R., Manikandan, R., Cho, J., & Veerappampalayam Easwaramoorthy, S. (2025). Multi scale multi attention network for blood vessel segmentation in fundus images. Scientific Reports, 15(1), 3438.
Kemkes. (2023). Pedoman Nasional Pelayanan Kedokteran : Tata Laksana Retinopati Diabetika. Kementerian Kesehatan Republik Indonesia, 1–36.
Li, Z., Jia, M., Yang, X., & Xu, M. (2021). Blood Vessel Segmentation of Retinal Image Based on Dense-U-Net Network. Micromachines, 12, 1478. https://doi.org/https://doi.org/10.3390/mi12121478
Liu, C., Gu, P., & Xiao, Z. (2022). Multiscale U-Net with Spatial Positional Attention for Retinal Vessel Segmentation. Journal of Healthcare Engineering, 2022. https://doi.org/10.1155/2022/5188362
Mudjirahardjo, P. (2024). The effect of grayscale, CLAHE image and filter images in convolution process. Int. J. Adv. Multidiscip. Res. Stud, 4(3), 943–946.
PODDAR, D. K., BANERJEE, P., BANERJEE, A., SAHA ROY, R., & PAUL, R. (2026). Digital Image Transformation and Enhancement Using Blurring, Cartoonization, Grayscale Conversion, and Edge Detection in Python. Cartoonization, Grayscale Conversion, and Edge Detection in Python (February 21, 2026).
Qi, Y., Yang, Z., Sun, W., Lou, M., Lian, J., Zhao, W., … Ma, Y. (2022). A comprehensive overview of image enhancement techniques. Archives of Computational Methods in Engineering, 29(1), 583–607.
Research Software Engineers. (2012). DRIVE: Digital Retinal Images for Vessel Extraction. Retrieved from Grand Challenge website: https://drive.grand-challenge.org/
Wardhani, A. S., Anggraeny, F. T., & Rizki, A. M. (2024). Penerapan Model Hibrida Cnn-Knn Untuk Klasifikasi Penyakit Mata. JATI (Jurnal Mahasiswa Teknik Informatika), 8(3), 3662–3667.
Yao, T., Qu, C., Liu, Q., Deng, R., Tian, Y., Xu, J., … Fogo, A. B. (2021). Compound figure separation of biomedical images with side loss. MICCAI Workshop on Deep Generative Models, 173–183. Springer.
You, Z., Yu, H., Xiao, Z., Peng, T., & Wei, Y. (2023a). CAS-UNet: a retinal segmentation method based on attention. Electronics, 12(15), 3359.
You, Z., Yu, H., Xiao, Z., Peng, T., & Wei, Y. (2023b). CAS-UNet: A Retinal Segmentation Method Based on Attention. Electronics (Switzerland), 12(15). https://doi.org/10.3390/electronics12153359
Yu, Y., Wang, C., Fu, Q., Kou, R., Huang, F., Yang, B., … Gao, M. (2023). Techniques and challenges of image segmentation: A review. Electronics, 12(5), 1199.
Zhao, M., Liu, Q., Jha, A., Deng, R., Yao, T., Mahadevan-Jansen, A., … Huo, Y. (2021). VoxelEmbed: 3D instance segmentation and tracking with voxel embedding based deep learning. International Workshop on Machine Learning in Medical Imaging, 437–446. Springer.
Downloads
Published
Issue
Section
License
Copyright Transfer StatementThe copyright of this article is transferred to Informatika Mulawarman : Jurnal Ilmiah Ilmu Komputer and when the article is accepted for publication. the authors transfer all and all rights into and to paper including but not limited to all copyrights in the Informatika Mulawarman. The author represents and warrants that the original is the original and that he/she is the author of this paper unless the material is clearly identified as the original source, with notification of the permission of the copyright owner if necessary. The author states that he has the authority and authority to make and carry out this task.
The author states that:
- This paper has not been published in the same form elsewhere.
- This will not be submitted elsewhere for publication prior to acceptance/rejection by this Journal.
A Copyright permission is obtained for material published elsewhere and who require permission for this reproduction. Furthermore, I / We hereby transfer the unlimited publication rights of the above paper to Informatika Mulawarman : Jurnal Ilmiah Ilmu Komputer. Copyright transfer includes exclusive rights to reproduce and distribute articles, including reprints, translations, photographic reproductions, microforms, electronic forms (offline, online), or other similar reproductions.
The author's mark is appropriate for and accepts responsibility for releasing this material on behalf of any and all coauthor. This Agreement shall be signed by at least one author who has obtained the consent of the co-author (s) if applicable. After the submission of this agreement is signed by the author concerned, the amendment of the author or in the order of the author listed shall not be accepted.
Rights / Terms and Conditions Saved
- The author keeps all proprietary rights in every process, procedure, or article creation described in Work.
- The author may reproduce or permit others to reproduce the work or derivative works for the author's personal use or for the use of the company, provided that the source and the Informatika Mulawarman copyright notice are indicated, the copy is not used in any way implying the Journal of Informatika Mulawarman (JIM) approval of the product or service from any company, and the copy itself is not offered for sale.
- Although authors are permitted to reuse all or part of the Works in other works, this does not include granting third-party requests to reprint, republish, or other types of reuse.

Informatika Mulawarman by http://e-journals.unmul.ac.id/index.php/JIM/index is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
under the CC BY-SA license, authors and other users are able to reprint, distribute or use the material for commercial purposes so long as they give attribution to the journal Informatika Mulawarman and license the republished material under the same license.